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Cephaeline dihydrochloride

Name: Cephaeline dihydrochloride
Brand: TargetMol
SKU: TQ0109
Price: 42 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TQ0109Cas No. 5853-29-2

Alias NSC32944, NSC 32944, (-)-Cephaeline dihydrochloride

Cephaeline dihydrochloride is a naturally occurring alkaloid that is a selective CYP2D6 inhibitor with an IC50=121 μM. It has an affinity for and oral activity at the 5-HT4 receptor and is capable of inducing vomiting.

Cephaeline dihydrochloride

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Purity: 99.67%

Catalog No. TQ0109Alias NSC32944, NSC 32944, (-)-Cephaeline dihydrochlorideCas No. 5853-29-2

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$42	-	In Stock
5 mg	$98	-	In Stock
10 mg	$147	-	In Stock
25 mg	$297	-	In Stock
1 mL x 10 mM (in DMSO)	$116	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.67%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Cephaeline dihydrochloride is a naturally occurring alkaloid that is a selective CYP2D6 inhibitor with an IC50=121 μM. It has an affinity for and oral activity at the 5-HT4 receptor and is capable of inducing vomiting.
Targets&IC50	CYP2D6:121 μM, CYP3A4:1000 μM
In vitro	In human liver microsome assays, Cephaeline dihydrochloride demonstrated weak inhibition of major cytochrome P450 (CYP) enzymes. Specifically, Cephaeline dihydrochloride inhibited CYP2D6 with an IC₅₀ of 121 μM and a Ki of 54 μM via competitive inhibition, and CYP3A4 with an IC₅₀ of 1000 μM and a Ki of 355 μM via non-competitive inhibition[1].
Synonyms	NSC32944, NSC 32944, (-)-Cephaeline dihydrochloride

Chemical Properties

Molecular Weight	539.53
Formula	C₂₈H₄₀Cl₂N₂O₄
Cas No.	5853-29-2
Smiles	COC(C=C(CCN1C[C@@H]2CC)C([C@]1([H])C[C@@H]2C[C@@H]3C4=CC(OC)=C(O)C=C4CCN3)=C5)=C5OC.Cl.Cl
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 200 mg/mL (370.69 mM), Sonication is recommended.

H2O: 100 mg/mL (185.35 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8535 mL	9.2673 mL	18.5347 mL	92.6733 mL
5 mM	0.3707 mL	1.8535 mL	3.7069 mL	18.5347 mL
10 mM	0.1853 mL	0.9267 mL	1.8535 mL	9.2673 mL
20 mM	0.0927 mL	0.4634 mL	0.9267 mL	4.6337 mL
50 mM	0.0371 mL	0.1853 mL	0.3707 mL	1.8535 mL
100 mM	0.0185 mL	0.0927 mL	0.1853 mL	0.9267 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc